Rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome - neuro-endocrine tumours (ROHHAD-NET): case series and learning points.
Katherine A C HawtonTom HilliardSimon C Langton-HewerChristine BurrenElizabeth C CrowneJulian P Hamilton-ShieldDinesh GiriPublished in: Journal of pediatric endocrinology & metabolism : JPEM (2023)
High prolactin was a consistent early feature. Central hypoventilation and NET may present later and therefore regular sleep studies and screening for NETs are required. A high suspicion of ROHHAD is warranted in patients with rapid, early-onset obesity and hyperprolactinaemia without structural pituitary abnormality.
Keyphrases
- early onset
- insulin resistance
- metabolic syndrome
- weight loss
- late onset
- type diabetes
- high fat diet induced
- weight gain
- positive airway pressure
- loop mediated isothermal amplification
- machine learning
- oxidative stress
- physical activity
- heart rate variability
- obstructive sleep apnea
- deep learning
- case report
- sleep quality
- skeletal muscle
- growth hormone
- blood pressure
- quantum dots
- neural network