Neuroimaging Correlates of Patient-Reported Outcomes in Multiple Sclerosis.

Dejan JakimovskiTaylor R WicksNiels BergslandMichael G DwyerBianca Weinstock-Guttman Robert Zivadinov

Published in: Degenerative neurological and neuromuscular disease (2023)

PRO measures of lower extremity limitations were associated with DGM structures and DGM-specific nuclei. These findings promote the relevance of measuring DGM structures as measures directly related to subjective well-being and walking limitations. Depression is a significant mediator of PROs and in particular of life satisfaction.

Keyphrases

patient reported outcomes
multiple sclerosis
high resolution
sleep quality
depressive symptoms
white matter
anti inflammatory
drug induced