Progenitor Hierarchy of Chronic Myelomonocytic Leukemia Identifies Inflammatory Monocytic-Biased Trajectory Linked to Worse Outcomes.
Meghan C Ferrall-FairbanksAbhishek DhawanBrian JohnsonHannah NewmanVirginia O VolpeChristopher T LetsonMarkus BallAnthony M HunterMaria E BalasisTraci KruerNana Adjoa Ben-CrentsilJodi L KroegerRobert BalderasRami S KomrokjiDavid A SallmanJing ZhangRafael BejarPhilipp M AltrockEric PadronPublished in: Blood cancer discovery (2022)
Our findings establish that multiple differentiation states underlie CMML disease progression. These states are negatively augmented by inflammation and positively affected by hypomethylating agents. Furthermore, we identify HSC depletion and expansion of GMP-like cells with increased cytokine receptor diversity as a feature of myeloblast expansion in inflammatory chronic myeloid neoplasms. This article is highlighted in the In This Issue feature, p. 476.