Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.
Hailiang HuangPriya DuggalChloe L ThioRachel LatanichJames J GoedertAlessandra MangiaAndrea L CoxGregory D KirkShruti MehtaJasneet AnejaLaurent AlricSharyne M DonfieldMatthew E CrampSalim I KhakooLeslie H ToblerMichael BuschGraeme J AlexanderHugo R RosenBrian R EdlinFlorencia P SegalGeorg M LauerDavid L ThomasMark J DalyRaymond T ChungArthur Y KimPublished in: Scientific reports (2017)
Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe.
Keyphrases
- genome wide association study
- copy number
- hepatitis c virus
- genome wide
- hepatitis c virus infection
- air pollution
- liver failure
- human immunodeficiency virus
- high resolution
- dna methylation
- respiratory failure
- intensive care unit
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- genome wide association