An open science study of ageing in companion dogs.
Kate E CreevyJoshua M AkeyMatt KaeberleinDaniel E L Promislownull nullPublished in: Nature (2022)
The Dog Aging Project is a long-term longitudinal study of ageing in tens of thousands of companion dogs. The domestic dog is among the most variable mammal species in terms of morphology, behaviour, risk of age-related disease and life expectancy. Given that dogs share the human environment and have a sophisticated healthcare system but are much shorter-lived than people, they offer a unique opportunity to identify the genetic, environmental and lifestyle factors associated with healthy lifespan. To take advantage of this opportunity, the Dog Aging Project will collect extensive survey data, environmental information, electronic veterinary medical records, genome-wide sequence information, clinicopathology and molecular phenotypes derived from blood cells, plasma and faecal samples. Here, we describe the specific goals and design of the Dog Aging Project and discuss the potential for this open-data, community science study to greatly enhance understanding of ageing in a genetically variable, socially relevant species living in a complex environment.
Keyphrases
- genome wide
- quality improvement
- healthcare
- public health
- endothelial cells
- electronic health record
- dna methylation
- induced apoptosis
- metabolic syndrome
- mental health
- cardiovascular disease
- minimally invasive
- big data
- health information
- social media
- cell death
- endoplasmic reticulum stress
- data analysis
- climate change
- genetic diversity