Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1.

Tahira BalochVanessa M López-OzunaQiong WangEmad MatanisRoy KessousLiron KoganAmber YasmeenWalter H Gotlieb

Published in: BMC cancer (2019)

Pre-treatment with PARPi followed by standard chemotherapy in vitro is more efficient in growth inhibition and induction of apoptosis compared to the administration of standard chemotherapy followed by PARPi.

Keyphrases

locally advanced
oxidative stress
endoplasmic reticulum stress
cell death
cancer therapy
squamous cell carcinoma
rectal cancer
combination therapy
drug delivery