Mind Your Ears: A New Antidote to Aminoglycoside Toxicity?
Mary E O'SullivanAlan G ChengPublished in: Journal of medicinal chemistry (2017)
Aminoglycoside antibiotics are known toxins to cochlear hair cells, causing permanent hearing loss. Using the zebrafish lateral line system as a platform for drug screen and subsequent validation in the rat cochlea in vivo, Chowdhury et al. characterized a novel otoprotectant working against aminoglycoside-induced hearing loss.
Keyphrases
- hearing loss
- pseudomonas aeruginosa
- acinetobacter baumannii
- induced apoptosis
- oxidative stress
- high throughput
- diabetic rats
- cell cycle arrest
- high glucose
- drug induced
- cystic fibrosis
- multidrug resistant
- drug resistant
- minimally invasive
- endoplasmic reticulum stress
- signaling pathway
- cell death
- emergency department
- endothelial cells
- cell proliferation
- pi k akt