The Effect of Self-Paced Exercise Intensity and Cardiorespiratory Fitness on Frontal Grey Matter Volume in Cognitively Normal Older Adults: A Randomised Controlled Trial.
Natalie J FrostMichael WeinbornGilles E GignacYing XiaVincent DoréStephanie R Rainey-SmithShaun MarkovicNicole GordonHamid R SohrabiSimon M LawsRalph N MartinsJeremiah J PeifferBelinda M BrownPublished in: Journal of the International Neuropsychological Society : JINS (2021)
At an aggregate level, six months of self-paced high- or moderate-intensity exercise did not increase frontal GM volume. However, experimentally-induced changes in individual cardiorespiratory fitness was positively associated with frontal GM volume in our sample of older adults. These results provide evidence of individual variability in exercise-induced fitness on brain structure.