TLR4/Inflammasomes Cross-Talk and Pyroptosis Contribute to N-Acetyl Cysteine and Chlorogenic Acid Protection against Cisplatin-Induced Nephrotoxicity.
Amira M BadrLayla A AlkharashiHala A AttiaSamiyah AlshehriHanaa N AlajamiRehab A AliYasmen F MahranPublished in: Pharmaceuticals (Basel, Switzerland) (2023)
This study emphasizes that inhibition of TLR4/NLPR3/IL-1β/GSDMD might be a novel mechanism of the nephroprotective effects of NAC or CGA against Cp-induced nephrotoxicity in rats.