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DARK Classics in Chemical Neuroscience: Methaqualone.

Joseph A IngerElias R MihanJhansi U KolliDennis C LiottaAaron M Bender
Published in: ACS chemical neuroscience (2023)
Commonly known as "Quaaludes," methaqualone ( 1 ) is a sedative-hypnotic medication, with effects resembling barbiturates and other downers, that exerts its effects through modulation of γ-aminobutyric acid type A receptors (GABA A R). Following the discovery of the sedative and euphoric effects of methaqualone ( 1 ), it was quickly adopted by pharmaceutical companies and promoted by clinicians around the world as a "safe" sleeping pill option, and for a period it was available over the counter. The popularity of methaqualone ( 1 ) soared worldwide, and many people began to use it recreationally for its sedative-hypnotic-like psychoactive effects. Not long after its introduction, many individuals began to misuse the drug leading to overdoses and drug dependence which brought to light methaqualone's ( 1 ) addictive nature. In this review, the background, synthesis, pharmacology, metabolism, and pharmacokinetics of methaqualone ( 1 ) will be covered along with its discovery, history, and the derivatives that are currently available around the world through manufacture in clandestine laboratories.
Keyphrases
  • small molecule
  • healthcare
  • palliative care
  • chronic pain
  • high throughput