Mitogen-activated protein kinase signaling in childhood asthma development and environment-mediated protection.
Johanna TheodorouElisabeth NowakAndreas BöckMichael SalvermoserClaudia C BeerweilerKathrin ZeberPaulina KuligMiranda S TsangChun-Kwok WongGary Wing Kin WongMarjut RoponenJörg KumbrinkFahd AlhamdanFlorian MichelHolger GarnVinko TosevskiBianca SchaubPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2021)
Lower DUSP1 baseline levels in asthmatic children and anti-inflammatory regulation of MAPK in several immune cell types by farm-dust stimulation indicate a regulatory function for DUSP1 for future therapy contributing to anti-inflammatory characteristics of farming environments.
Keyphrases
- anti inflammatory
- lung function
- chronic obstructive pulmonary disease
- signaling pathway
- young adults
- oxidative stress
- transcription factor
- current status
- tyrosine kinase
- human health
- pi k akt
- health risk
- protein kinase
- health risk assessment
- cystic fibrosis
- early life
- polycyclic aromatic hydrocarbons
- childhood cancer
- risk assessment
- climate change