A Phase II Study of Allogeneic GM-CSF-Transfected Pancreatic Tumor Vaccine (GVAX) with Ipilimumab as Maintenance Treatment for Metastatic Pancreatic Cancer.
Annie A WuKatherine M BeverWon Jin HoElana J FertigNan NiuLei ZhengRose M ParkinsonJennifer N DurhamBeth OnnersAnna K FergusonCara WiltAndrew H KoAndrea Wang-GillamDaniel A LaheruRobert A AndersElizabeth D ThompsonElizabeth A SugarElizabeth D ThompsonDung T LePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
GVAX and ipilimumab maintenance therapy did not improve OS over continuation of chemotherapy and resulted in a numerically inferior survival in metastatic PDA. However, clinical responses and biological effects on immune cells were observed. Further study of novel combinations in the maintenance treatment of metastatic PDA is feasible.