Colorectal Cancer Develops Inherent Radiosensitivity That Can Be Predicted Using Patient-Derived Organoids.

Kuo-Shun HsuMohammad AdilehMaria Laura MartinVladimir MakarovJiapeng Chen Chao Wu Sahra BodoStefan KlinglerCharles-Etienne Gabriel Sauvé Bryan C Szeglin J Joshua SmithZvi FuksNadeem RiazTimothy A ChanMakoto NishimuraPhilip B PatyRichard Kolesnick

Published in: Cancer research (2022)

Analysis of inherent tissue radiosensitivity of patient-derived organoids may provide a readout predictive of neoadjuvant therapy response to radiation in rectal cancer, potentially allowing pretreatment stratification of patients likely to benefit from this approach.

Keyphrases

rectal cancer
end stage renal disease
locally advanced
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
lymph node
radiation therapy
patient reported outcomes
induced pluripotent stem cells
patient reported