Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention Initiative.
Rachel PearlmanWendy L FrankelBenjamin J SwansonDan JonesWeiqiang ZhaoAhmet YilmazKristin MillerJason BacherChristopher BigleyLori NelsenPaul J GoodfellowRichard M GoldbergElectra D PaskettPeter G ShieldsJo L FreudenheimPeter P StanichIlene LattimerMark ArnoldThomas W PriorMitchell HautMatthew F KaladyBrandie H LeachIan PaquetteDavid J DraperJoanna M BrellSameer MaheshKisa WeemanShyamal BastolaJeffrey ZangmeisterAruna GowdaFilix KencanaAlbert MalcolmYinong LiuSharon ColeCharles BaneChaoyang LiEsther RehmusColin C PritchardBrian H ShirtsAngela JacobsonShelly A CummingsAlbert de la ChapelleHeather HampelPublished in: JCO precision oncology (2021)
UTS alone is insufficient for identifying a large proportion of CRC patients with hereditary syndromes, including some with LS. At a minimum, 7.1% of individuals with CRC have a PGV and pan-cancer MGPT should be considered for all patients with CRC.