The role of LRRK2 in cytoskeletal dynamics.
Laura CivieroSusanna CogoAlice BiosaGreggio ElisaPublished in: Biochemical Society transactions (2018)
Leucine-rich repeat kinase 2 (LRRK2), a complex kinase/GTPase mutated in Parkinson's disease, has been shown to physically and functionally interact with cytoskeletal-related components in different brain cells. Neurons greatly rely on a functional cytoskeleton for many homeostatic processes such as local and long-distance vesicle transport, synaptic plasticity, and dendrites/axons growth and remodeling. Here, we will review the available data linking LRRK2 and the cytoskeleton, and discuss how this may be functionally relevant for the well-established roles of LRRK2 in intracellular trafficking pathways and outgrowth of neuronal processes in health and disease conditions.
Keyphrases
- induced apoptosis
- healthcare
- protein kinase
- mental health
- cell cycle arrest
- tyrosine kinase
- spinal cord
- cerebral ischemia
- white matter
- big data
- multiple sclerosis
- reactive oxygen species
- cell proliferation
- risk assessment
- social media
- oxidative stress
- blood brain barrier
- machine learning
- endoplasmic reticulum stress
- health promotion
- deep learning