Muscarinic M4 and M5 receptors in the ventral subiculum differentially modulate alcohol seeking versus consumption in male alcohol-preferring rats.

Leigh C WalkerKate L HuckstepNicola A ChenLexi J HandCraig W LindsleyChristopher J Langmead Andrew J Lawrence

Published in: British journal of pharmacology (2021)

Collectively, our data highlight alcohol-induced cholinergic dysregulation in the vSub and distinct roles for M4 and M5 receptor allosteric modulators to reduce alcohol consumption or seeking.

Keyphrases

alcohol consumption
small molecule
mental health
spinal cord
diabetic rats
big data
machine learning
deep brain stimulation
spinal cord injury
drug induced