Mitochondrial transfer from bone mesenchymal stem cells protects against tendinopathy both in vitro and in vivo.

Bing WeiMingliang JiYucheng LinShanzheng WangYuxi LiuRui GengXinyue HuLi XuZhuang LiWeituo ZhangJun Lu

Published in: Stem cell research & therapy (2023)

MSCs rescued distressed tenocytes from apoptosis by transferring mitochondria. This provides evidence that mitochondrial transfer is one mechanism by which MSCs exert their therapeutic effects on damaged tenocytes.

Keyphrases

mesenchymal stem cells
oxidative stress
umbilical cord
cell death
bone marrow
cell therapy
bone mineral density
endoplasmic reticulum stress
stem cells
cell cycle arrest
platelet rich plasma
rotator cuff
electron transfer
reactive oxygen species
bone loss
cell proliferation
pi k akt