Induction effect of antiretroviral bictegravir on the expression of Abcb1, Abcg2 and Abcc1 genes associated with P-gp, Bcrp and Mrp1 transporters present in rat peripheral blood mononuclear cells.

Bictegravir activates nuclear receptors enhancing efflux transporterexpression. Understanding these interactions is crucial for preventing drug-druginteractions and reducing toxicity in clinical use. Combining Car antagonistswith bictegravir may prevent drug resistance and toxicity. However, thesefindings are based on preclinical data and necessitate further clinical trialsto confirm their applicability in clinical settings.