Subgroups of patients with young-onset type 2 diabetes in India reveal insulin deficiency as a major driver.

Rashmi B Prasad Olof Asplund Sharvari R Shukla Rucha Wagh Pooja KunteDattatrey BhatMalay Parekh Meet Shah Sanat Phatak Annemari Käräjämäki Anupam Datta Sanjeeb Kakati Tiinamaija Tuomi Banshi Saboo Emma Ahlqvist Leif C Groop Chittaranjan S Yajnik

Published in: Diabetologia (2021)

Our data identified insulin deficiency as the major driver of type 2 diabetes in young Indians, unlike in young European individuals in whom obesity and insulin resistance predominate. Our results provide useful clues to pathophysiological mechanisms and susceptibility to complications in type 2 diabetes in the young Indian population and suggest a need to review management strategies.

Keyphrases

type diabetes
insulin resistance
glycemic control
middle aged
cardiovascular disease
metabolic syndrome
high fat diet
adipose tissue
high fat diet induced
risk factors
polycystic ovary syndrome
body mass index
deep learning
physical activity
genome wide
gene expression