Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles.

Gang-Wei WangOlivia BoydTom A Young Sophie M Bertrand John F Bower

Published in: Journal of the American Chemical Society (2020)

We outline a conceptual blueprint that provides direct and atom economical access to a wide range of complex polyheterocycles. Our method capitalizes on the ambiphilic reactivity of rhodacyclopentanones that arise upon exposure of cyclopropanes to Rh(I) catalysts and CO. Using this approach, a wide array of polycyclizations are achieved, including variants that involve powerful dearomatizations and medium ring formations.

Keyphrases

molecular dynamics
copy number
electron transfer
highly efficient
high resolution
high throughput
dna methylation
transition metal