Transcriptional Changes in Chronic Rhinosinusitis with Asthma Favor a Type 2 Molecular Endotype Independent of Polyp Status.

Amarbir S GillAbigail PulsipherJorgen S SumsionGretchen M OakleyLaurie W LeclairHeather HoweRichard R OrlandiJeremiah A Alt

Published in: Journal of asthma and allergy (2021)

Patients with CRSsNP-A demonstrate a molecular endotype associated with a Th2-dominant inflammatory profile compared to CRSsNP. Patients with CRSwNP-A similarly demonstrate an overrepresentation of genes associated with Th2-driven inflammation compared to patients with CRSwNP.

Keyphrases

chronic rhinosinusitis
oxidative stress
chronic obstructive pulmonary disease
gene expression
single molecule
lung function
allergic rhinitis
cystic fibrosis