Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features.

Ji Hyae LimYu-Jung KangHye Jin BakMi Sun KimHyun Jung LeeDong Wook KwakYou Jung HanMoon Young KimHyeyeon BooShin Young KimHyun Mee Ryu

Published in: Clinical epigenetics (2020)

This is the first study to investigate the genome-scale DNA methylation profiles of PE placentas according to severe features. The epigenetic variation in the placentas probably resulted in altered developmental processes and immune dysregulation, contributing to PE. This study provides basic information to refine the clinical and pathological mechanisms of the severe features in placenta-mediated PE.

Keyphrases

dna methylation
genome wide
gene expression
early onset
drug induced
copy number