Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK.

Naru MoritaToshio HosakaAtsuko KitaharaToshitaka MurashimaHirohisa OnumaYoshikazu SumitaniKazuto TakahashiToshiaki TanakaTakuma KondoHitoshi Ishida

Published in: Journal of diabetes research (2018)

MCP-1 release from hypertrophied adipocytes is suppressed by AMPK activation through the NF-κB and ERK pathways. These findings provide evidence that AMPK plays a crucial role in ameliorating obesity-induced inflammation.

Keyphrases

signaling pathway
oxidative stress
diabetic rats
skeletal muscle
high glucose
adipose tissue
high fat diet induced
insulin resistance
metabolic syndrome
type diabetes
drug induced
protein kinase
weight loss
cell proliferation
endothelial cells
lps induced
body mass index
nuclear factor