Combination of cafeteria diet with intraperitoneally streptozotocin in rats. A type-2 diabetes model.
Mirelly Marques Romeiro SantosAndressa Carolina Farias Pereira Subtil CavalcanteLuane Aparecida do AmaralGabriel Henrique Oliveira de SouzaBárbara Suzuki Dos SantosLuciane Candeloro PortugalFelipe Francisco Bittencourt JuniorThiago TroquezBruna Paola Murino RafachoPriscila Aiko HianeElisvânia Freitas Dos SantosPublished in: Acta cirurgica brasileira (2021)
The results show that the experimental model using cafeteria diet associated with 35 mg/kg of STZ is a low-cost model and efficient in order to develop DM2, confirmed by the presence of polydipsia, hyperglycemia, altered biochemical tests, insulin resistance and damages to the liver, pancreas and kidney, which is similar to the disease found in humans.