Clinico-genomic Characterization of ATM and HRD in Pancreas Cancer: Application for Practice.
Wungki ParkCatherine A O'ConnorChaitanya BandlamudiDaniella F FadenJoanne F ChouShigeaki UmedaMarsha ReyngoldMarjorie G ZaudererFergus KeaneFiyinfolu BalogunKenneth H YuDavid P KelsenChristopher H CraneMarinela CapanuChristine A Iacobuzio-DonahueEileen M O'ReillyPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
ATM variants in PDAC represent a distinct biologic group and appear to have favorable OS. Nonetheless, pathogenic ATM variants do not confer an HRD signature in PDAC and ATM should be considered as a non-core HR gene in this disease.