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Clinico-genomic Characterization of ATM and HRD in Pancreas Cancer: Application for Practice.

Wungki ParkCatherine A O'ConnorChaitanya BandlamudiDaniella F FadenJoanne F ChouShigeaki UmedaMarsha ReyngoldMarjorie G ZaudererFergus KeaneFiyinfolu BalogunKenneth H YuDavid P KelsenChristopher H CraneMarinela CapanuChristine A Iacobuzio-DonahueEileen M O'Reilly
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
ATM variants in PDAC represent a distinct biologic group and appear to have favorable OS. Nonetheless, pathogenic ATM variants do not confer an HRD signature in PDAC and ATM should be considered as a non-core HR gene in this disease.
Keyphrases
  • copy number
  • dna damage
  • dna damage response
  • dna repair
  • rheumatoid arthritis
  • primary care
  • papillary thyroid
  • healthcare
  • genome wide
  • dna methylation
  • squamous cell
  • quality improvement
  • young adults
  • childhood cancer