Effects of molecularly targeted therapies on murine thymus: highly selective mTOR inhibitors induce reversible thymic involution.

Suleiman Al-HammadiSaeeda AlmarzooqiAlia AlbawardiAbdul-Kader Souid

Published in: Experimental hematology & oncology (2016)

Thus, the highly-selective mTOR inhibitors imposed specific effects on the thymus, manifested by suppression of cellular respiration and induction of apoptosis.

Keyphrases

cell proliferation
oxidative stress
cell death
cell cycle arrest
pi k akt