Coiled-coil inspired functional inclusion bodies.
Marcos Gil-GarciaSusanna NavarroSalvador VenturaPublished in: Microbial cell factories (2020)
Here, we present a proof of concept for the use of a natural coiled-coil domain as a versatile tool for the production of functional IBs in bacteria. This α-helix-based strategy excludes any potential toxicity drawback that might arise from the amyloid nature of β-sheet-based IBs and renders highly active and homogeneous submicrometric particles.
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