A computational assessment of pH-dependent differential interaction of T7 lysozyme with T7 RNA polymerase.

Published in: BMC structural biology (2017)

Since T7L has been used for developing novel therapeutics and T7RNAP one of the most biologically useful protein in both in-vitro and in vivo experiments, this in silico study of pH dependent conformational differences in T7L and the differential interaction with T7RNAP at different pH can provide a significant insight into the structural investigations on T7L and T7RNAP in varying pH environments.

Keyphrases

small molecule
molecular docking
molecular dynamics simulations
amino acid
binding protein