Palladium-Catalyzed Asymmetric Tandem [3+2] Cycloaddition/Allylation Reaction of Methylene-Trimethylenemethane: Access to Chiral Tricyclic Dinitrogen-Fused Heterocycles.

A palladium-catalyzed asymmetric tandem [3+2] cycloaddition/allylation of methylene-trimethylenemethane is presented, providing the functionalized chiral hexahydropyrazolo[5,1- a]isoquinoline derivatives in high yields with good to excellent enantioselectivities and moderate to good E: Z ratios. In the one-pot sequential tandem reactions/hydroxylation, ( E)-allylic alcohol products were obtained in good yields with excellent enantioselectivities.