Relevance of Molecular Groups in Children with Newly Diagnosed Atypical Teratoid Rhabdoid Tumor: Results from Prospective St. Jude Multi-institutional Trials.
Santhosh A UpadhyayaGiles W RobinsonArzu Onar-ThomasBrent A OrrPascal JohannGang WuCatherine A BillupsRuth G TatevossianSandeep Kumar DhandaAshok SrinivasanAlberto BroniscerIbrahim QaddoumiAnna VinitskyGregory T ArmstrongAnne E BendelTimothy Eg HassallSonia PartapPaul G FisherJohn R CrawfordMurali ChintagumpalaEric BouffetSridharan GururanganRoya MostafaviRobert P SandersPaul KlimoZoltan PatayDaniel J IndelicatoKim E NicholsFrederick A BoopThomas E MerchantMarcel KoolDavid W EllisonAmar J GajjarPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Among infants, those with ATRT-TYR had the best OS. ATRT-SHH was associated with metastases and consequently with inferior outcomes. Children with nonmetastatic ATRT benefit from postoperative CSI and adjuvant chemotherapy.