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Bone Marrow Failure Syndromes, Overlapping Diseases with a Common Cytokine Signature.

Valentina GiudiceChiara CardamoneMassimo TriggianiCarmine Selleri
Published in: International journal of molecular sciences (2021)
Bone marrow failure (BMF) syndromes are a heterogenous group of non-malignant hematologic diseases characterized by single- or multi-lineage cytopenia(s) with either inherited or acquired pathogenesis. Aberrant T or B cells or innate immune responses are variously involved in the pathophysiology of BMF, and hematological improvement after standard immunosuppressive or anti-complement therapies is the main indirect evidence of the central role of the immune system in BMF development. As part of this immune derangement, pro-inflammatory cytokines play an important role in shaping the immune responses and in sustaining inflammation during marrow failure. In this review, we summarize current knowledge of cytokine signatures in BMF syndromes.
Keyphrases
  • immune response
  • bone marrow
  • mesenchymal stem cells
  • dendritic cells
  • toll like receptor
  • oxidative stress
  • single cell
  • gene expression
  • genome wide
  • dna methylation