What does heritability of Alzheimer's disease represent?
Emily SimmondsGanna LeonenkoKarl Michael SchmidtMatthew HillAmanda J MyersMaryam ShoaiItziar De RojasNiccoló TesiHenne HolstegeWiesje Maria van der FlierYolande A L PijnenburgAgustin RuizJohn HardySven van der LeeValentina Escott-PricePublished in: PloS one (2023)
The heritability of neurodegenerative disorders cannot be represented as a single number, because it is dependent on the ages of cases and controls. Genome-wide association studies pick up a large proportion of total AD heritability when age and genetic architecture are correctly accounted for. Around 13% of SNP-based heritability can be explained by known genetic loci and the remaining heritability likely resides around microglial related genes.