Silencing TCF4 Sensitizes Melanoma Cells to Vemurafenib Through Inhibiting GLUT3-Mediated Glycolysis.

Can LiuSiqi HeJianfei ZhangShiyan LiJian ChenChaofei Han

Published in: OncoTargets and therapy (2020)

Our study demonstrates that TCF4 downregulation sensitizes melanoma cells to vemurafenib through inhibiting GLUT3-mediated glycolysis. These findings support TCF4 as an oncogene and provide new mechanism by which TCF4 confers chemotherapy resistance in melanoma.

Keyphrases

signaling pathway
induced apoptosis
cell proliferation
locally advanced
oxidative stress
radiation therapy
endoplasmic reticulum stress
skin cancer