Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder.

Jochen HessPatrick StelmachAndreas EisenhardtHerbert RübbenHenning ReisKurt Werner SchmidHagen Sjard Bachmann

Published in: Journal of cancer research and clinical oncology (2017)

In our cohort, both c.-938C>A and c.21G>A showed a significant impact on outcome with TCC of the bladder. Due to the linkage disequilibrium of both SNPs, maybe, only one of them could mediate this effect. In multivariable analysis, however, both proved to be independently associated with overall survival. Contrary to other findings which found the c.-938C>A mainly influencing outcome, our data may suggest that the main effect on TCC could be due to the c.21G>A polymorphism.

Keyphrases

spinal cord injury
genome wide
electronic health record
machine learning
gene expression
big data
dna methylation