Laminaria japonica fucoidan ameliorates cyclophosphamide-induced liver and kidney injury possibly by regulating Nrf2/HO-1 and TLR4/NF-κB signaling pathways.
Shanshan TianXiaoxia JiangYunping TangTao HanPublished in: Journal of the science of food and agriculture (2021)
Our studies suggest that fucoidan can ameliorate CTX-induced liver and kidney injury, potentially via up-regulating the Nrf2/HO-1 pathway and inhibiting the TLR4/NF-κB pathway. © 2021 Society of Chemical Industry.
Keyphrases
- signaling pathway
- pi k akt
- oxidative stress
- diabetic rats
- nuclear factor
- toll like receptor
- high glucose
- inflammatory response
- lps induced
- immune response
- low dose
- induced apoptosis
- drug induced
- epithelial mesenchymal transition
- high dose
- endothelial cells
- cell proliferation
- escherichia coli
- multidrug resistant
- case control
- stress induced