Neutrophil extracellular trap regulators in sickle cell disease: Modulation of gene expression of PADI4, neutrophil elastase, and myeloperoxidase during vaso-occlusive crisis.

Bidossessi Wilfried HounkpeFrancine ChenouIgor de Farias DomingosEvilazio Cunha CardosoMarcondes José de Vasconcelos Costa SobreiraAderson S AraujoAntonio Roberto Lucena-AraújoPedro Vieira da Silva NetoAdriana MalheiroNelson Abrahim FraijiFernando Ferreira CostaMarcos André C BezerraMagnun Nueldo Nunes SantosErich Vinicius De Paula

Published in: Research and practice in thrombosis and haemostasis (2020)

Higher levels of gene expression of PADI4 and ELANE were observed during VOC. Furthermore, plasma activity of PADI4 was higher in acute VOC when compared to healthy individuals. These results demonstrate that NETosis regulators are modulated during acute VOC, and pave the way for studies of PADI4 inhibition as a therapeutic strategy for acute VOC in SCD.

Keyphrases

sickle cell disease
gene expression
liver failure
respiratory failure
drug induced
dna methylation
aortic dissection
transcription factor
public health
hepatitis b virus
intensive care unit
mechanical ventilation