Activation of angiotensin type 2 (AT2) receptors prevents myocardial hypertrophy in Zucker diabetic fatty rats.

Giovanna CastoldiCira R T di GioiaFrancesca RomaRaffaella CarlettiGiuseppina ManzoniAndrea StellaGianpaolo ZerbiniGianluca Perseghin

Published in: Acta diabetologica (2018)

Activation of AT2 receptors or AT1 receptor blockade prevents the development of myocardial hypertrophy in ZDF rats. This occurs through the modulation of the miR-30a-3p/PTEN interaction.

Keyphrases

left ventricular
type diabetes
cell proliferation
mouse model
angiotensin ii
pi k akt
heart failure
wound healing
signaling pathway