M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt/GSK-3β/β-catenin pathway in mice.

Bin QianYang YangNingyuan TangJiahui WangPeng SunNan YangFang ChenTijun WuTong SunYating LiXiaoai ChangYunxia ZhuYaqin Zhang Xiao Han

Published in: Diabetologia (2021)

A novel exosome-modulated mechanism was delineated for macrophage-beta cell crosstalk that drove beta cell dysfunction and should be explored for its therapeutic utility.

Keyphrases

single cell
signaling pathway
cell therapy
stem cells
metabolic syndrome
insulin resistance
pi k akt