Synergistic effect of elevated glucose levels with SARS-CoV-2 spike protein induced NOX-dependent ROS production in endothelial cells.
Jiahao ZhangLi HeRong HuangJuan Felipe AlvarezDavid H YangQihao SunFengqin WangZhiyong PengNanhui JiangLianjiu SuPublished in: Molecular biology reports (2023)
Our present study provides evidence for a mechanism through which hyperglycemia aggravates endothelial cell injury resulting from S protein mediated activation of the ACE2-NOX axis. Our research thus highlights the importance of strict monitoring and control of blood glucose levels within the context of COVID-19 treatment to potentially improve clinical outcomes.
Keyphrases
- blood glucose
- sars cov
- endothelial cells
- high glucose
- reactive oxygen species
- glycemic control
- respiratory syndrome coronavirus
- diabetic rats
- coronavirus disease
- blood pressure
- amino acid
- cell death
- vascular endothelial growth factor
- binding protein
- type diabetes
- skeletal muscle
- dna damage
- angiotensin ii
- replacement therapy
- smoking cessation
- weight loss