Empagliflozin Improves Diastolic Function in HFpEF by Restabilizing the Mitochondrial Respiratory Chain.

Antje Schauer Volker Adams Susanne KämmererErik LangnerAntje AugsteinPeggy BarthelAnita MännelGunar Fabig Paula Ketilly Nascimento AlvesMario GünschtAli El-Armouche Thomas Müller-ReichertAxel LinkeEphraim B Winzer

Published in: Circulation. Heart failure (2024)

The study demonstrates beneficial effects of Empa on diastolic function, hemodynamics, inflammation, and cardiac remodeling in a rat model of HFpEF. These effects were mediated by improved mitochondrial respiratory capacity due to modulated cardiolipin and improved calcium handling.

Keyphrases

left ventricular
oxidative stress
blood pressure
ejection fraction
heart failure
respiratory tract