Topical application of polymeric nanomicelles in ophthalmology: a review on research efforts for the noninvasive delivery of ocular therapeutics.
Maria Aurora GrimaudoSilvia PescinaCristina PadulaPatrizia SantiAngel ConcheiroCarmen Alvarez-LorenzoSara NicoliPublished in: Expert opinion on drug delivery (2019)
Although still a few, in vivo experiments have clearly demonstrated the capability of polymeric nanomicelles to overcome a variety of hurdles associated to ocular therapy, notably increasing drug bioavailability. However, there are still some very important issues to be solved, such as tolerability and stability; additionally, the role of micelles in drug uptake by the ocular tissues and their potential for the treatment of posterior eye diseases still need to be clarified/verified.
Keyphrases
- drug delivery
- drug release
- cancer therapy
- optic nerve
- open label
- gene expression
- small molecule
- artificial intelligence
- stem cells
- adverse drug
- emergency department
- clinical trial
- drug induced
- mesenchymal stem cells
- quality improvement
- risk assessment
- climate change
- optical coherence tomography
- cell therapy
- human health
- double blind