The pathogenic role of circulating Hashimoto's Thyroiditis-derived TPO-positive IgG on fetal loss in naïve mice.
Elena BorodinaItai KatzAlessandro AntonelliAlexander M GzgzyanLiailia Kh DzhemlikhanovaYuri OstrinskiDariko NiauriJamilya Kh KhizroevaViktoriya O BitsadzeAlexander MakatsariyaAngela TincaniCecilia NalliLeonid P ChurilovOra ShovmanGilad HalpertMiri BlankYehuda ShoenfeldHoward AmitalPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)
The current study shows in the first time, a direct proof of concept, on the association of human TPO-positive IgG from Hashimoto's thyroiditis patients on fetal loss induction in murine model.