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Exploring molecular glioblastoma: Insights from advanced imaging for a nuanced understanding of the molecularly defined malignant biology.

Michael GriessmairClaire DelbridgeJulian ZiegenfeuterKirsten JungTobias MuellerSeverin SchrammDenise BernhardtFriederike Schmidt-GrafOlivia KertelsMarie ThomasClaus ZimmerBernhard MeyerStephanie E CombsIgor YakushevBenedikt WiestlerMarie-Christin Metz
Published in: Neuro-oncology advances (2024)
Quantitative analysis of diffusion and perfusion parameters shows potential in reflecting the malignant tumor biology of molGB. It may increase awareness of molGB in a nonenhancing, "benign" appearing tumor. Our results support the emerging hypothesis that molGB might present glioblastoma captured at an early stage of gliomagenesis.
Keyphrases
  • early stage
  • high resolution
  • squamous cell carcinoma
  • magnetic resonance imaging
  • risk assessment
  • single molecule
  • human health
  • contrast enhanced
  • radiation therapy
  • mass spectrometry