Silymarin inhibits the progression of Ehrlich solid tumor via targeting molecular pathways of cell death, proliferation, angiogenesis, and metastasis in female mice.
Maggie E AmerMaher A AmerIbrahim M El-SherbinyDoaa A ElsayedMohamed Amr El-MissiryOmar A AmmarPublished in: Molecular biology reports (2022)
The anticancer effect was associated with apparent apoptosis in neoplastic cells with abundance of multifocal necrotic areas. SMN was found to inhibit ET growth via enhancing apoptosis, inhibition of cell division and reduction in angiogenesis in vivo. Hypothetical scheme of SMN antitumor effects (mechanism of signaling) in solid ET in vivo. SMN anticancer effect may be mediated by molecular mediators that affect proliferation, cell cycle activity, apoptotic pathways, angiogenesis, and metastasis.
Keyphrases
- cell death
- cell cycle arrest
- cell cycle
- endothelial cells
- signaling pathway
- pi k akt
- vascular endothelial growth factor
- oxidative stress
- cell proliferation
- induced apoptosis
- wound healing
- stem cells
- single cell
- cancer therapy
- adipose tissue
- type diabetes
- metabolic syndrome
- high fat diet induced
- wild type
- wastewater treatment