Cystatin F acts as a mediator of immune suppression in glioblastoma.

Emanuela SenjorMilica Perišić NanutBarbara BreznikAna MitrovićJernej MlakarAna RotterAndrej PorčnikTamara Lah TurnšekJanko Kos

Published in: Cellular oncology (Dordrecht) (2021)

Our data implicate cystatin F as a mediator of immune suppression in glioblastoma. Increased cystatin F mRNA and protein levels in immune, glioblastoma and glioblastoma stem-like cells or trans internalized cystatin F may have an impact on decreased susceptibility of glioblastoma cells to NK cytotoxicity.

Keyphrases

induced apoptosis
cell proliferation
binding protein
electronic health record
cell death
endoplasmic reticulum stress
signaling pathway
data analysis