Rare coding variants in RCN3 are associated with blood pressure.
Karen Y HeTanika N KellyHeming WangJingjing LiangLuke ZhuBrian E CadeThemistocles L AssimesLewis C BeckerAmber L BeitelsheesLawrence F BielakAdam P BressJennifer A BrodyYen-Pei Christy ChangYi-Cheng ChangPaul S de VriesRavindranath DuggiralaErvin R FoxNora FranceschiniAnna L FurnissYan GaoXiuqing GuoJeffrey HaesslerYi-Jen HungShih-Jen HwangMarguerite Ryan IrvinRita R KalyaniChing-Ti LiuChunyu LiuLisa Warsinger MartinMay E MontasserPaul M MuntnerStanford MwasongweTake NaseriWalter PalmasMuagututi'a Sefuiva ReupenaKenneth M RiceWayne H-H SheuDaichi ShimboJennifer A SmithBeverly M SnivelyLisa R YanekWei ZhaoJohn BlangeroEric BoerwinkleYii-Der Ida ChenAdolfo CorreaL Adrienne CupplesJoanne E CurranMyriam FornageJiang HeLifang HouRobert C KaplanSharon L R KardiaEimear E KennyCharles KooperbergDonald Lloyd-JonesRuth J F LoosRasika A MathiasStephen T McGarveyBraxton D MitchellKari E NorthPatricia A PeyserBruce M PsatyLaura M RaffieldD C RaoSusan RedlineAlex P ReinerStephen S RichJerome I RotterKent D TaylorRussell TracyRamachandran S Vasannull nullAlanna C MorrisonDaniel LevyAravinda ChakravartiDonna K ArnettXiaofeng ZhuPublished in: BMC genomics (2022)
Low frequency and rare variants in RCN3 contributes blood pressure variation. This study demonstrates that focusing association analyses in linkage regions greatly reduces multiple-testing burden and improves power to identify novel rare variants associated with blood pressure traits.