Functionalized gold nanoparticles: promising and efficient diagnostic and therapeutic tools for HIV/AIDS.
Shikha GulatiParinita SinghAnchita DiwanAyush MongiaSanjay KumarPublished in: RSC medicinal chemistry (2020)
Functionalized gold nanoparticles are recognized as promising vehicles in the diagnosis and treatment of human immunodeficiency virus (HIV) owing to their excellent biocompatibility with biomolecules (like DNA or RNA), their potential for multivalency and their unique optical and structural properties. In this context, this review article focuses on the diverse detection abilities and delivery and uptake methodologies of HIV by targeting genes and proteins using gold nanoparticles on the basis of different shapes and sizes in order to promote its effective expression. In addition, recent trends in gold nanoparticle mediated HIV detection, delivery and uptake and treatment are highlighted considering their cytotoxic effects on healthy human cells.
Keyphrases
- human immunodeficiency virus
- gold nanoparticles
- antiretroviral therapy
- hiv aids
- hiv infected
- hiv positive
- hepatitis c virus
- reduced graphene oxide
- quantum dots
- hiv testing
- dna methylation
- loop mediated isothermal amplification
- label free
- genome wide
- climate change
- real time pcr
- risk assessment
- nucleic acid
- south africa
- circulating tumor
- gene expression
- long non coding rna
- sensitive detection