Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells.
Matthew B JohnsonKashyap A PatelElisa De FrancoWilliam HagopianMichael KillianTimothy James McDonaldTimothy I M TreeClara Domingo-VilaMichelle HudsonSuzanne HammersleyRebecca Dobbsnull nullSian EllardSarah E. FlanaganAndrew T HattersleyRichard D OramPublished in: Diabetologia (2020)
We provide strong evidence that type 1 diabetes can present before the age of 6 months based on individuals with this extremely early-onset diabetes subtype having the classic features of childhood type 1 diabetes: high genetic risk, autoimmunity and rapid beta cell loss. The early-onset association with reduced birthweight raises the possibility that for some individuals there was reduced insulin secretion in utero. Comprehensive genetic testing for all neonatal diabetes genes remains essential for all individuals diagnosed with diabetes at <6 months of age. Graphical abstract.
Keyphrases
- type diabetes
- early onset
- glycemic control
- late onset
- cardiovascular disease
- insulin resistance
- genome wide
- induced apoptosis
- single cell
- weight loss
- cell cycle arrest
- loop mediated isothermal amplification
- cell therapy
- stem cells
- mesenchymal stem cells
- metabolic syndrome
- young adults
- signaling pathway
- skeletal muscle
- celiac disease
- copy number
- quantum dots
- transcription factor
- pi k akt
- genome wide identification
- bioinformatics analysis
- childhood cancer