Developmental regression and mitochondrial function in children with autism.

Kanwaljit SinghIndrapal N SinghEileen DigginsSusan L ConnorsMohammad A KarimDavid LeeAndrew W ZimmermanRichard Eugene Frye

Published in: Annals of clinical and translational neurology (2020)

This study suggests that individuals with ASD and DR may represent a unique metabolic endophenotype with distinct abnormalities in respiratory function that may put their mitochondria in a state of vulnerability. This may allow physiological stress to trigger mitochondrial decompensation as is seen clinically as DR. Since mitochondrial function was found to be related to ASD symptoms, the mitochondria could be a potential target for novel therapeutics. Additionally, identifying those with vulnerable mitochondrial before DR could result in prevention of ASD.

Keyphrases

autism spectrum disorder
editorial comment
intellectual disability
attention deficit hyperactivity disorder
oxidative stress
cell death
young adults
reactive oxygen species
climate change
endoplasmic reticulum
small molecule
risk assessment
sleep quality