Three-Component Ruthenium-Catalyzed meta -C-H Alkylation of Phenol Derivatives.

Herein, we realized the multicomponent reactions of phenol derivatives via a six-membered cycloruthenated intermediate for the first time. This strategy exhibited good substrate suitability and functional group tolerance with various phenol derivatives and provided a potential synthetic drug approach. Mechanistic studies showed that a radical might be involved in this process. In addition, the meta alkylated phenol was obtained by further removal of the directing group.